Experimental intervertebral disc degeneration models

Intervertebral disc degeneration is a major health problem of close concern to both young and old. The also growing as the global population ages. defined progressive changes affecting spine component natural aging under effect multiple factors (such smoking, obesity, incorrect exercise). For solution be found, experimental must first induced, causes disease identified, early diagnostic therapeutic methods then developed. Methods inducing intervertebral with high applicability in rats were identified from previous literature. This review discusses four induction. It how detect formation development times. As result literature review, information about different reliable presented.